Alpha-2B adrenergic receptor 0.1 mg Alpha-2B adrenergic receptor 0.05 mg

Source: Chicken

 Purity: Immunoaffinity Purified

 Clonality: Polyclonal

 Crossreactivity: Human

 Format: Phosphate-Buffered Saline. No preservatives added.

 Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

 Stability: 6-12 months at -20 degree C.

 Shipping: Products may be shipped on ice pack or dry ice. 
 
 ADRA2B ANTIBODY TARGET DESCRIPTION:
Synonym Names for ADRA2B antibody: ADRA2B; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; Alpha-2 adrenergic receptor subtype C2; Alpha-2B-adrenergic receptor; alpha-2-adrenergic receptor-like 1

Function: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.

Subcellular Location: Membrane; multi-pass membrane protein.

Polymorphism: A rare polymorphic framshift in position 451 produces a protein of 542 residues.

Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].

Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This protein is the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This protein contains no introns in either its coding or untranslated sequences.

Alpha-2B adrenergic receptor reacts with human.

OMIM: 104260; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Neuroactive ligand-receptor interaction 04080 
 
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 APPLICATIONS for ADRA2B ANTIBODY:
 WB: Tested
 ELISA, ICC, IHC: Not Tested