Staurosporine - 100 mg

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO or ethanol; insoluble in water.  Disposal:  A

Staurosporine is a potent inhibitor of many, many kinases including protein kinase C (IC50 = 0.7 nM), protein kinase A (IC50 = 7 nM), and protein kinase G (IC50 = 8.5 nM).  Matsumoto, H. and Sasaki, Y.  "Staurosporine, a protein kinase C inhibitor, interferes with proliferation of arterial smooth muscle cells."  Biochem. Biophys. Res. Commun. 158:  105-109 (1989).  Tamaoki, T., et al.  "Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase."  Biochem. Biophys. Res. Commun. 135:  397-402 (1986).

• Staurosporine induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons.  Boix, J., et al.  "Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines."  Neuropharmacology 36:  811-821 (1997).  Wiesner, D.A. and Dawson, G.,  "Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway."  J. Neurochem. 66:  1418-1425 (1996).

• Please request Technical Note #24 for additional information

• Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.