Cytochrome c 0.05 mg Cytochrome c 0.1 mg

 Source: Chicken

 Purity: Immunoaffinity Purified

 Clonality: Polyclonal

 Crossreactivity: Human

 Format: Phosphate-Buffered Saline. No preservatives added.

 Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

 Stability: 6-12 months at -20 degree C.

 Shipping: Products may be shipped on ice pack or dry ice. 
 
 CYCS ANTIBODY TARGET DESCRIPTION:
Synonym Names for CYCS antibody: CYCS; CYC; Cytochrome c

Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Function: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Subcellular Location: Mitochondrion; mitochondrial matrix.

Ptm: Binds 1 heme group per subunit.

Similarity: Belongs to the cytochrome c family.

Summary: This protein is cytochrome c, a component of the electron transport chain in mitochondria. The heme group of cytochrome c accepts electrons from the b-c1 complex and transfers electrons to the cytochrome oxidase complex. Cytochrome c is also involved in initiation of apoptosis. Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor which activates the apoptotic initiator procaspase 9. Many cytochrome c pseudogenes exist, scattered throughout the human genome.

Cytochrome c reacts with human.

OMIM: 123970; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Apoptosis 04210
KEGG pathway: Circadian rhythm 04710
KEGG pathway: Colorectal cancer 05210
Reactome Event:Apoptosis 109581
Reactome Event:Electron Transport Chain 163200

Products similar to CYCS antibody:
 IgG
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 IgY
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 PRODUCT INTERACTIONS:
 Cytochrome c interacts with Apoptotic protease-activating factor 1, IgY

 Cytochrome c interacts with Apoptotic protease-activating factor 1, IgG 

 Cytochrome c interacts with RABBIT ANTI APAF1 (aa12-28), IgG 

 Cytochrome c interacts with Anti-Apaf1 (Mouse) Monoclonal Antibody, IgG 
 
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more. 
 
 APPLICATIONS for CYCS ANTIBODY:
 WB: Tested
 ELISA, ICC, IHC: Not Tested