Alpha-2-macroglobulin 0.1 mg Alpha-2-macroglobulin 0.05 mg

Conjugation: Biotin

 Source: Chicken

 Purity: Immunoaffinity Purified

 Clonality: Polyclonal

 Crossreactivity: Human, mouse, rat

 Format: Format: Phosphate-Buffered Saline. 0.01% Sodium Azide added as preservative.

 Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

 Stability: 6-12 months at -20 degree C.

 Shipping: Products may be shipped on ice pack or dry ice. 
 
 A2M ANTIBODY TARGET DESCRIPTION:
Synonym Names for A2M antibody: A2M; Alpha-2-M; Alpha-2-macroglobulin [validated] - human

Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Subunit: Homotetramer; disulfide-linked.

Tissue Specificity: Plasma.

Developmental Stage: Contrary to the rat protein, which is an acute phase protein, this protein is always present at high levels in circulation.

Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family [view classification].

Alpha-2-macroglobulin (Biotin Conjugated) reacts with human, mouse, rat.

OMIM: 103950; gene+phenotype. [NCBI / EBI]

Products similar to A2M antibody:
 IgG
    LRP1 (low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)), IgG
    alpha 2 Macroglobulin antibody (HRP), IgG
    alpha 2 Macroglobulin antibody, IgG
    LRPAP1 (low density lipoprotein receptor-related protein associated protein 1), IgG
    alpha 2 Macroglobulin [1201] antibody, IgG
 
 
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