Beta-2 adrenergic receptor 0.05 mg Beta-2 adrenergic receptor 0.1 mg

Source: Chicken

 Purity: Immunoaffinity Purified

 Clonality: Polyclonal

 Crossreactivity: Human

 Format: Phosphate-Buffered Saline. No preservatives added.

 Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

 Stability: 6-12 months at -20 degree C.

 Shipping: Products may be shipped on ice pack or dry ice. 
 
 ADRB2 ANTIBODY TARGET DESCRIPTION:
Synonym Names for ADRB2 antibody: ADRB2; ADRB2R; B2AR; BAR; ADRBR; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; Adrenergic, beta-2-, receptor, surface

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Subunit: Binds SLC9A3R1 and GPRASP1.

Subcellular Location: Membrane; multi-pass membrane protein.

Ptm: Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation.

Ptm: Phosphorylated by PKA and BARK; mediate homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK.

Disease: Polymorphic forms of ADRB2 could impart some form of nocturnal asthma.

Similarity: Belongs to the G-protein coupled receptor 1 family [view classification].

Summary: This protein is beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This protein contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.

Beta-2 adrenergic receptor reacts with human.

OMIM: 109690; gene+phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Calcium signaling pathway 04020
KEGG pathway: Neuroactive ligand-receptor interaction 04080

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 IgY
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 APPLICATIONS for ADRB2 ANTIBODY:
 WB: Tested
 ELISA, ICC, IHC: Not Tested