Cyclosporin A - 1 g

COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Cyclosporin A
Synonyms: Cyclosporine, Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA, Sandimmune
Hazardous Ingredient: Cyclosporin A
CAS Registry Number: 59865-13-3
Molecular Weight: 1202.63
Molecular Formula: C62H111N11O12

HAZARDS IDENTIFICATION:
Hazard Description: potent immunosuppresant
RTECS Substance categories: Tumorigen; Drug; Mutagen; Reproductive effector
Exposure may cause irritation to eyes; mucous
membranes, upper respiratory tract and skin
Exposure may also cause the following: effect fertility and/or unborn child and breastfed infants;
lymphomas; convulsions; seizure or tremors; nutritional & gross metabolic changes; gastrointestinal
disturbances; cardiovascular changes; biochemical changes
Information pertaining to particular dangers for man and environment:
HMIS Ratings: Health =1 Flammability =0 Reactivity =0

FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove conact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: none known

ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

HANDLING AND STORAGE:
Information for safe handling: avoid inhalation and contact with skin, eyes, and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: white to off-white
Odor: none
Melting point/Melting range: 148-151ºC
Danger of explosion: none
Solubility in / Miscibility with water: not soluble
Solvent content: none
Organic solvents: soluble in DMSO or ethanol (1 mL of ethanol will dissolve 160 mg)

STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

TOXICOLOGICAL INFORMATION:
RTECS#: GZ4120000
Acute toxicity: none known
Primary irritant effect:
On the skin: may be harmful
On the eye: may be an irritant

ECOLOGICAL INFORMATION:
General notes: no data available

DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S22: Do not breathe dust
S23: Do not breathe vapour
S24/25: Avoid contact with skin and eyes
S28: After contact with skin, wash immediately with plenty of water
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
S60: This material and its container must be disposed of as hazardous waste
R20/21/22: Harmful by inhilation, in contact with skin and if swallowed
R45: May cause cancer
R60: May impair fertility
R62: Possible risk of impaired fertility
R63: Possible risk of harm to the unborn child
R68: Possible risk of irreversible effects