GTPase HRas 0.1 mg GTPase HRas 0.05 mg

 Source: Chicken

 Purity: Immunoaffinity Purified

 Clonality: Polyclonal

 Crossreactivity: Mouse, rat

 Format: Phosphate-Buffered Saline. No preservatives added.

 Storage: 4 degree C for short term (weeks) and -20 degree C for long term. Avoid frequent freeze and thaw.

 Stability: 6-12 months at -20 degree C.

 Shipping: Products may be shipped on ice pack or dry ice. 
 
 HRAS ANTIBODY TARGET DESCRIPTION:
Synonym Names for HRAS antibody: HRAS; HRAS1; K-ras; N-ras; RASH1; Transforming protein p21; p21ras; H-Ras-1; c-H-ras; V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1

Function: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme Regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Subcellular Location: Shuttles: Cell membrane; lipid-anchor; cytoplasmic side. Shuttles: Golgi apparatus; Golgi membrane; lipid-anchor.

Ptm: Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.

Disease: Defects in HRAS are the cause of Costello syndrome [MIM:218040]; also known as faciocutaneoskeletal syndrome. Costello syndrome is a rare condition characterized by prenatally increased growth, post-natal growth deficiency, mental retardation, distinctive facial appearance, cardiovascular abnormalities (typically pulmonic stenosis, hypertrophic cardiomyopathy and/or atrial tachycardia), tumor predisposition, skin and musculoskeletal abnormalities.

Disease: Mutations which change positions 12, 13 or 61 activate the potential of c-ras to transform cultured cells and are implicated in a variety of human tumors.

Disease: Defects in HRAS are a cause of bladder cancer [MIM:109800].

Disease: Defects in HRAS are also the cause of oral squamous cell carcinomas (OSCC).

Similarity: Belongs to the small GTPase superfamily. Ras family.

GTPase HRas reacts with mouse, rat.

OMIM: 109800; phenotype. [NCBI / EBI]
190020; gene. [NCBI / EBI]
218040; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Axon guidance 04360
KEGG pathway: B cell receptor signaling pathway 04662
KEGG pathway: Fc epsilon RI signaling pathway 04664
KEGG pathway: Focal adhesion 04510
KEGG pathway: Gap junction 04540
KEGG pathway: Glioma 05214
KEGG pathway: GnRH signaling pathway 04912
KEGG pathway: Insulin signaling pathway 04910
KEGG pathway: Long-term depression 04730
KEGG pathway: Long-term potentiation 04720
KEGG pathway: MAPK signaling pathway 04010
KEGG pathway: Natural killer cell mediated cytotoxicity 04650
KEGG pathway: Regulation of actin cytoskeleton 04810
KEGG pathway: T cell receptor signaling pathway 04660
KEGG pathway: Tight junction 04530
KEGG pathway: VEGF signaling pathway 04370
Reactome Event:Insulin receptor mediated signaling 74752

Products similar to HRAS antibody:
 IgG
    vH RAS [Y13-238] antibody, IgG
    p21 Ras [NCC-RAS-001] antibody, IgG
 
 
 PRODUCT INTERACTIONS:
 GTPase HRas interacts with RABBIT ANTI RAF-1 (pSer642), IgG 
 GTPase HRas interacts with RABBIT ANTI RAF-1 (pSer301), IgG
 GTPase HRas interacts with Raf1 (Phospho-Ser259), IgG
 GTPase HRas interacts with Raf1 (Ab-259), IgG
 
 
SUGGESTED ANITBODY REAGENTS - GenWay has an extensive selection of reagents useful for antibody applications. Find blocking buffers, stop reagents, chemiluminescent substrates, diluents, Immunohistochemistry reagents & more. 
 
 APPLICATIONS for HRAS ANTIBODY:
 WB: Tested
 ELISA, ICC, IHC: Not Tested