Pathway: Hs Spinal Cord Injury WP2431 84650

2151LEPNGFRLTB4CSPG4TNFSF13LTBMIFLGALS3PDYNPTPRZ1PLXNA2CD47TNFSF13BFECHP1CDC42APEX1C1QBNOAQP1AIF1LTB4R344044301651036481273836Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZFP36FCGR2APRB1PTPRAIL1BZFP36NOS2TNFNR4A150IL4BTG2BTG2FBRCDK2NOS1IL2TNFIL6TLR4FOSIL1BTGFB1TLR4TNFEGR1FOSMMP12IFNGGlial ScarAstrocyte GliosisSwelling/EdemaMBPAntigens ReleasedRTN4C5CXCL1Neutrophil ChemoattractantsCXCL82, 54NeurtrophilsMonocytesAQP427TTLegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating18Activated Microglia/Macrophages(Transient)RepairIL1BNOS2TNFARG1TOXIC FERROUSIRONFocal Adensions17, 31EPHA4TTEPHNB2TTTTTTTTCXCL10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)49CCNG1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMMP911TTChondroitin Sulfate ProteoglycansNCAN23SLIT1Axon Retraction23SLIT2SLIT3NTN1RGMATTTTTTTTTTMMP911MMP9MMP911TT11TTTTCCR2IL1R1TT54ECM BreakdownECM BreakdownIL1ACXCL1Monocyte Chemoattractants2, 54CXCL2CCL2OligodendrocyteInjury ResponsePLA2G6PLA2G5PLA2G2AmelittinInflammationDemyelinationANXA115TTTTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors41ICAM1SELPTTTTPlasticityKLK846TTMicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGFAPTT11IntermediateFillament14CDK4TACR1E2F5RB1PRKCAE2F1MAPK1CCND1MYCGADD45AMAPK3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationTP53CytotoxicCytotoxicCHST11VCANCOL4A1XYLT1COL2A1ACANBCANGlial Scar FromationSOX9Axonal GrowthInhibition14IgG, IgMTP53TT22TTTTGRIN1VIM2628TTT Cell StimulatingFK506189PPP3CATTFK506FK5061919GAP43TTFK50619Axonal RegenerationFKBP1AIL2C3 ToxinC1Q and Fc receptive cellsMAGRTN4RHOARHOCRHOBROCK2OMGRTN4RLILRB345MyelinInjury ResponseArachidonic acidPGH2PTGS21TT53ROSNOX4MIR23BOlomoucine35CDK1GDNF42TTSEMA6ATT34Axonal GrowthInhibitionGJA16ATP-ReleaseTTBDNFTTImmediate Response Genes2-Methoxyestradiol4916TTRAC1TTTTAstroctyeFOXO320TTCDKN1B20TTN2 Glial Precursor37EGFRPD 16839333TT43CASP3TTTT

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