Pathway: Hs Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways WP706 80056

43827627577010941111112094, 38, 1077188162912242642, 861445131, 6621723636113722396602312071253637120231237377536669122, 24, 593764607840784078794095114787868, 872895784878783540787895407954, 9554, 95Putative TRsSPhC825TGq signalingNerve TerminalK+CaStabilization2+TRrCell MembraneMiscelaneous SIDS AssociatedHeartInfant (<1 year in age)Associated with Energy Metabolism and SIDSG2989TDecreased relative SIDS expressionSarcoplasmic ReticulumFocal AdhesionsHNG5477ABradycardiaPutative TRPutative TRsBrainGi signalingIncreased long-QT with SIDSOtherPutative TRsPutative TRSIDS Susceptibility PathwaysSerotonin Synthesis and MetabolismSleepThermoregulationSerotoninTransporterPutative TRAssociated with Infection and SIDSK+Gs signaling2NucleusSoma MembraneSIDS associated polymorphismsPutative TRG-proteinVagal ToneTR: Transcriptional RegulationIncreased relative SIDS expression4R/4RHONa+SPhSPhdepressionPutative TRPutative TRsPutative TRTRrPutative TRsCardiac myocytePutative TRNHRapidly-activating K+ Currentp+Putative TRsSph: SIDS Phenotype Animal ModelNucleusPutative TRsrs2856966Increased brainstem hypoplasia with SIDSSPhcircadian BrownAdipose Slowly-Activating K+ CurrentSerotonin SignalingBrainstem neuronIVS-191_190insA11512335697119245669824RESTNR3C1KCNH2MAOACTCFYBX1MIR210TPH1CREB1GNB3TPH2SLC6A4FOXM1VIPR2PBX1GATA3THRBRETDDCCHRNA4HTR1APHOX2BPOU3F2JUNPPARGC1AKCNQ1RUNX3IL10KCNQ1SCN5AHIF1ATP735-HTCREB15-HTHIF1AIL6CC2D1ANGFTPH1FEVMIR16-1VIPR1MAOADEAF1TPH2EN1RESTMAZADCYAP1R1MEF2CCAV3MIR13AEP300BHLHE40CHRNB4HSPD1AVPFEVRESTPKNOX1GATA2C4BPOU3F2DLX2ADCYAP1SP1ADCYAP15-HTNR3C1Glial Cell DifferentiationHES1HES1SP3TNFNKX2-2RORACDCA7LRYR2SSTR2ECE1SSTR1ASCL1HTR1AKCNH2 NFKB1L-TryptophanSP1PPARGC1BRESTLMX1BNicotineSP1HES5FluoxetineNEUROD15-HTPC4AIL6RTLX3EGR1RYR2NFYAIL8CREBBPTACR1PLP1ESR2ALDOASP1DDCCREB1CAV3NKX3-1NFKB1HADHARESTARPHOX2ASP1TCF35-HIAAACADMHTR2A66102901183339171081108446526811741051365503212153673137112493096, 10449124100365Putative TRsCTNNB1SOX2NANOGPOU5F15MAPK pathway95BDNFNTRK2Gi signalingGABAGABRA183CHRM258GJA145SNTA1Na+H+14K+KCNJ8GJA1PKC inhibitor 14-3-3Protein Kinase APRKAR2BYWHAEYWHAZPRKAR1BPRKAR2AYWHAQYWHAGPRKAR1AYWHAHYWHABPRKACBPRKACAActivation55GAP JunctionSLC9A3CASP3FMO3G6PC61GCK85GPD1L25GRIN1HADHB80HTR3ASCN3BSCN4BSSTNa+Cardiac VagalExcitationChronicHypoxia925-HTGlutamateCa2+106H2OH2OAQP4ApoptosisCPT1A101IL1AIL1B6IL1RN6IL136389TSPYL1VEGFA7715SCN5A18DopaminePhenylalanineCHATL-DOPAPAHAcetylcholineCholineTHTyrosineDDC98NOS1APGq signalingMAP241TAC1MicrotubleStabilizationSLC1A3SLC25A4GlutamateSNAP25Synaptic Vesicle ReleaseGlutamateSST4141TAC1HTR3A76TH82CHAT35114SLC9A3BDNF95NTRK2AQP410670GRIN1SP199NFKB2JUNHDAC99473MYBCEBPB57SNTA145GPD1LSP1JUNNR3C1REST4419JUNCREB1POU2F247CREMRESTNFKB1CHRNB2CHRNA7Serotonergic NeuronsHDAC1MBD1MECP2NFKB1CREBBPTRrTRrGABRA183CREB181VAMP2Extracellular SpacePutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsPutative TRsTPPPATP1A3GAPDHHSP90B1TFSPTBN1YWHAGHIF1APutative TRs12536

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