Pathway: Hs Vitamin B12 Metabolism WP1533 85340

28, 97, 122, 148, 152...13357, 109, 261, 292, 29930, 177, 292Nitrogen CompundsReactionConversionStimulationBiomarker forSelenoproteinsMicronutrientsLEGENDBindingCofactor conversionOther proteinsInhibitionSelenium statusCleavageOverarching processNecessary stimulationEnzymesis composed ofNegative EffectCatalysisTranscription factorProtein with polymorphismProcess or metabolism involved in Se PathwayMetabolitesCofactorsProtein*From intracellular part to the plasmaIntracellularPlasmaCUBNHCLipid peroxidationPGF2aIF*PGE1TCN2*8-Isoprostaglandin F2aF2-IsoprostaneMCP1Protein tyrosine nitrationPGE2PGE1Lipoprotein metabolismMCP1DNA OxidationRELAMegalinThromboxane B2Thromboxane A2PGF2aa-TocopherolTCN2*Thromboxane B28-Isoprostaglandin F2aThromboxane B2PGE2a-TocopherolNFkB2Prostaglandin metabolismF2-IsoprostaneNFkB1213, 33873, 96, 108, 190, 203...134, 249, 255, 291, 318...120, 34296, 108, 190123, 15373, 96, 100, 108, 190...10410410414, 96, 108, 190161124, 187134, 249, 255, 291, 318...123, 1533177171, 115, 12068128, 280119, 120, 18144, 96, 344119, 120, 181120, 3427110420, 44, 96, 108, 190...71128, 280, 302CBRMMABMM-CoA-HMCEEMUTMTR*MATMSR*SHMT10858, 89, 100, 1124, 1592558, 216224, 305103, 107, 108, 112, 212...26, 60, 964CBS207, 313NADHNADP+NADP+NADP+MPO69, 139, 299, 331CysteinePAI-1ThrombinFactor VIItPAPAI-1PLGFactor VIIPLGtPAThrombin48, 240565648, 2055648, 20556565648, 240H2O25,10-Methylene-THF305, 323Creatinine5-methyl-THFCreatinine5-methyl-THF30, 177, 212, 310, 312...245, 273245, 27330, 177, 212, 310, 312...SOD3SOD3CTH313THF323NADPHNADPHNADPHNADMTHFR*107, 323HomocysteineHomocysteine92, 123, 199, 201, 205...92, 123, 199, 201, 205...SOD1Pyridoxal 5'-phosphatePyridoxal 5'-phosphate46, 123, 147, 310, 31246, 123, 147, 310, 312SerineSerine224, 305224, 305HDLCholesterolAPOEoxLDLAPOA1SAA4VLDLTAGSRB1HDL/SAASAA3APOBHDLLDL-CVLDLABCA1VLDL/APOBTAGHDL/APOA1LDLSAA2APOA1-NO2TyrLDL-CACTACTLDLRCholesteroloxLDLHDL-CLDL/APOBSAA1APOA1HDL-CVLDL-TAGVLDL-TAGAPOBLDL294169, 307180, 304307180, 290180, 29030730720, 193, 307128, 139, 231, 291, 338169, 270, 307150, 294169, 307166, 294270, 30730787128, 139, 231, 291, 338307294307150, 304169, 30729429429430720, 128, 193, 307270157, 194157, 194, 253150, 294166, 294157, 194, 253128, 139, 231, 291, 338128, 139, 231, 291, 338169, 307AdenosylcobalaminVitamin B12/CobalaminFAD8-OHdGVitamin B12/CobalaminMethylcob(III)alaminMethylcob(III)alamin8-OHdGCob(II)alaminCob(I)alaminAdenosylcobalamin11258, 89, 108, 11255, 58, 89, 108, 11230, 58, 108, 17796, 108, 190, 253, 273...16130, 58, 108, 17726, 10829, 96, 108, 189, 190, 228...26, 108161vitamin DChlorinevitamin DChlorine253253CystathionineSOD2ZincZincNO2N2ONO3-HOClNOO3HNO269, 201, 279, 33160, 103, 279sICAM-1IL6IL10HbA1cHbA1cINSRIL10FibrinogenALBFibrinHBA1D-dimerIL1BRANTESINSIL1BTNFaIL6HBBFibrinALBCRPINSD-dimerFibrinogenTNFaRANTES56, 24081, 136, 228, 26181, 233, 31256, 9581, 26159148, 3025928, 181, 261122170, 35429, 152, 170, 181, 209...44, 26418, 124, 136, 209, 291...59170, 189, 346170, 189, 346152, 170, 209, 261122199, 209, 274148, 3025956, 24056, 9528, 26181, 233, 31244, 264RiboflavinRiboflavin253, 272253, 272O2L-Methylmalonyl-CoACbl/IFMethionineD-Methylmalonyl-CoA Methylmalonic acid S-Adenosylhomocysteine Methylmalonic acid S-AdenosylmethionineCbl/TC S-AdenosylmethionineCbl/TCCbl/HCMethionine S-Adenosylhomocysteine Succinyl-CoA4, 26, 60, 282212, 221, 32396, 108, 1904, 26, 965, 25, 58, 112, 32396, 108, 190, 27326, 96212, 221, 32396, 108, 19078, 3234, 26, 964, 2678, 32396, 108, 1905, 25, 58, 112, 323ONOO-ONOOHNitrotyrosine68GlucoseFructosamineFructosamineGlucose26459, 34659, 346264Ascorbic acidAscorbic acidAscorbic acid93, 134, 255, 31893, 134, 255, 31893, 134, 255, 318

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