Pathway: Mm Lung fibrosis WP3632 86204

MatrixmetalloproteinasesTGF betasignalingCytokinesand inflammatoryresponseDifferentiationPathwayApoptosisNRF2signalingToll-like receptorsignaling84GPCRsignalingRegulation ofreactive oxygen speciesmetabolismGTPaseactivatorChemokinesignalingPulmonary fibrosisFibroblastproliferation, resistance to apoptosis, differentiationinto myofibroblasts, collagen productionStressfibre assemblyPulmonary surfactantproteinsExcess deposition and/or reduced turnover of extracellular matrix (ECM)Macrophage-relatedfrustrated phagocytosis, oxidative stressandinflammasome activationMIESalivarysecretion5Epithelial injury andapoptosis:disturbed interactionwith mesenchymal cells,epithelial-mesenchymaltransition TelomereorganizationSerine-typepeptidase activityLeukocyte/Myeloid celldifferentiationIntermediatefilamentcytoskeletonMethylation/chromatin bindingChondrocytedifferentiationLung injury (known or unknown) combined with tissue response (normal or abnormal)4Rtel1Cxcl2 Spp1Dpp9Fgf1Ccl4Smad7 TercCtgfSFTPA2ParnMAPKsignalingCcl2 SERPINA1Skil TnfSftpa1Il6Oxidative StressEdn1ElnCsf3 Grem1InflammasomeactivationDsp3TertMecp2Cxcl15Obfc1CalcaTgfaIl13Il1bCcr3 Ccl5Pdgfa NADPHoxidaseCcl11Atp11aFgf2InflammationCma1Il5Coagulation disturbancesEgf Timp1 NF-KBIl12bBmp7Pdgfb Ptx3Nfe2l2Mmp9Fgf7Muc5bCebpbCysltr2Hmox1 p38 MAPKMmp2 HgfSftpcCcr2Il4Csf2 Elmod2PlauFam13aCcl3Mt2Igf1 Tgfb1Collagen productionROSproduction3Additional non-connected genes with direct association topulmonary fibrosis in the Comparative Toxicogenomics Database (CTD)2All genes in the network are directly associated withpulmonary fibrosis in the Comparative Toxicogenomics Database (CTD)2, 6ROSproduction3NF-KBInflammasomeactivationKE13KE1/KE355KE1/KE35KE1/KE25KE3/KE4KE355KE3/KE45KE35KE4KE455KE5AO5KE1/KE25AE15AE15AE155AE25AE1KE3/KE455KE3/KE4KE355

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