Pathway: Mm Primary Focal Segmental Glomerulosclerosis FSGS WP2573 79651

1-7PPKATT: Therapeutic Target (increase)SLIT DIAPHRAGMDISRUPTIONAD: Autosomal RecessiveCALCIUMMICRORNA 193AACTINAPOPTOSISCALCINEURINAR: Autosomal DominantTT: Therapeutic Target (decrease)Legend+P13KF-ACTINACTIN3P21PODOCYTOPENIAPodocyte-Associated Genetic Glomerular DiseasesPROTEIN17Q25GENEARSTABILIZES PODOCYTECYTOSKELETONMATERNAL10Q23PRIMARY INJURYESRDARARNUCLEUS11P15.5NonsyndromicSyndromicPRIMARY FSGSAR15Q21-Q229Q33.3TYPE4Q21.1Kirrel3YwhaqNck1AgrnFynCtslJag1Tgfb1PlaurIrf6Camk2bPtproKirrel2Dnm1SynpoItgb3Lama5Tlr4Ptk2ItgavVclCd151VtnDkk1Akt1Cd2apCsAKrt8Nphs2Lamb2Nphs1Plcg1Cdkn1bRITUXIMABCr1lPax2PodxlLmx1bMyo1eScarb2MT-TL1Myo1eFat1Lmx1bItgb4MT-TL1Col4a5Cdkn1cMmeMYCOPHENOLATE MOFETILVimCdkn1aCd151PodxlNphs1Plce1Cd2apACTN4Myh9Smarcal1Wt1Inf2Trpc6AACTININ4Cd2apPlce1Nphs2Nphs1Myh9Smarcal1Wt1Inf2Trpc61Q25-Q3119Q136P12.311P132Q3519Q13.122Q12.311Q21-2214QCHROMOSOMETRANSMISSIONARARADAD/ARADADADARCOMPLEXLamb2Itgb4Cd151ARScarb2ARADWt1PcnaMki67Cdh2Cldn1DESTRUCTION OFPODOCYTEARCHITECTURENUCLEUSPODOCYTETTWt1SynpoCol4a3Col4a4ACTN4GLOMERULAR BASEMENT MEMBRANENORMAL PODOCYTELims1Nphs1Nphs2Cd80Notch1+P-SynpoGLOMERULAR BASEMENT MEMBRANETTTTTTTTTTTTTTTTTTTTTTTTTTCtnnb1Notch1Lrp6Lrp5TTTTTTTrpc6TTTTTTTTTTTTTTTTTTTTTTGLOMERULAR BASEMENT MEMBRANENORMALEPITOPESPAXTTANTICLA4TTTln1IlkItgb1Itga3Proteins involved in Podocyte cytoskeletonDag1PARVAIlkUtrnWNT1Y-SECRETASE

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